In Axiom Nexus, General Optimus Prime found himself inducted into the Convoy, a group of Optimus Primes and their kin dedicated to safeguarding the multiverse. While the other Convoy members tended to stay in the upper reaches of Axiom Nexus, the General was able to use his unusual appearance for an Optimus Prime to venture in the Offworlder zones without suspicion, a great help to Offworlder Zone Security Administration Commander Cheetor. The General was also assisted in his new mission by his longtime scout, Sergeant Hound. General Optimus Prime profile card Sgt. Hound profile card

Optimus Prime appears in the prequel novel Transformers: Ghosts of Yesterday, where he and a group of Autobots travel in the Ark searching for the Allspark, battling Starscream's Decepticons along the way. While going through a worm hole, the Autobots find themselves encountering a group of humans in a spacecraft reverse-engineered from studying Megatron. With this discovery, Prime realizes the significance of Earth, as both Megatron and the Allspark are there. After saving Bumblebee from a pit of rock-chewing cave worms, Prime battles Starscream. He is about to be gunned down by Starscream and Bonecrusher when he is saved by the human craft. In retaliation, Starscream obliterates it.
When Sideswipe was accused and convicted of destroying the Nova Suspension Bridge, Optimus was infuriated that one of his own Autobots could commit such a heinous act. Optimus was tasked to hunt down and deactivate Sideswipe, though the task proved to be easy as Sideswipe did not run, hide or resist. After Optimus had deactivated Sideswipe, he was approached by Prowl, who pointed out that Sideswipe's actions made little sense, as he had committed the crime in broad daylight before many witnesses. Agreeing that the Decepticons might be behind the situation, Optimus allowed Prowl to take a team of Autobots to Carob Island to clear Sideswipe's name while Optimus and Jazz stayed behind to continue working on human/Autobot relations. Prowl returned with evidence that it was indeed a Decepticon-controlled clone of Sideswipe that had committed the crime. Optimus then presumably reactivated Sideswipe when his name was cleared. Deadly Paradise 
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