Optimus and his Autobots were aboard the Ark, on the run from the Decepticons. With him, Optimus had what Megatron was forever seeking; the AllSpark! With the ship taking heavy damage from the Autobots' pursuers, Optimus ordered Jazz to take them into an emergency quantum jump. Jazz informed Prime that the jump would take longer to initiate than the time the Decepticons would need to board their vessel. As such, Optimus entrusted the AllSpark to Bumblebee while he and the rest of the bridge crew steeled themselves to hold off their enemies. Thanks to Starscream breaking rank in the Decepticons' formation, Optimus was able to hold back Megatron, and with Heatwave's help, repel them from the ship just as it initiated the quantum jump. However, at that moment the AllSpark tumbled off-ship, falling into the quantum tunnel and seemingly being lost for good... Angry Birds Transformers #1
In Transformers: Decepticons, Optimus Prime lands on Earth along with the other Autobots to stop the Decepticons. Optimus does not appear until Megatron is released and Starscream escapes with the Allspark. Optimus fights Megatron, but is defeated and is killed while Megatron gives chase to his traitorous second-in-command. In the 2009 Revenge of the Fallen video game by Activision, Optimus Prime is among the playable characters.
China.Org has reported of a potential Beast Wars movie as well as the (still rumored) Optimus Prime movie. Bumblebee movie producer, Lorenzo di Bonaventura was also careful to state that the chances of subsequent movies are riding on the success of Bumblebee at the Box Office. He also mentioned the animated movie was in its writing stage, though with other titles already riding on Bumblebee's success – being in the writing stage doesn't exactly guarantee even the animated movie's - Read More
Optimus Prime has appeared in numerous video games since the introduction of the Transformers series. He makes a cameo in the 1999 Beast Wars Transmetals video game for Nintendo 64, where he is killed by Megatron at the end of the campaign, showing what would have happened in the Beast Wars series with a Predacon victory. Prime is also one of the playable characters in the 2003 Japan-only Transformers game for the PlayStation 2 and the 2010 Transformers: War for Cybertron. Optimus Prime is also playable in the Hasbro Net Jet Transformers fighting game Transformers Battle Universe. Three versions of Optimus Prime are playable characters, including the first generation incarnation, his incarnations from the 2007 live-action film, and the incarnation from Transformers Animated. In this game, Optimus Primal is also a playable character. He is a regular character in the Nintendo GameCube and PlayStation 2 2003 fighting game DreamMix TV World Fighters. He appeared as a boss in a simple Flash-based video game on the Hasbro web site.
If Optimus allowed the cured Autobots to charge headlong into battle, he and the rest of the Autobots who were still running low on fuel stayed behind as back-up to the main charge. The Autobots’ first wave of warriors were quickly overpowered by the arrival of Megatron, prompting Optimus to lead the energy-depleated Autobots into the fray. Optimus’s opening volley struck down Shockwave. Optimus and his troops soon found themselves running on empty, and Optimus called for a retreat. Thankfully, the Decepticons were damaged enough through the course of the battle, causing them to retreat as well.
Revenge of the Fallen Legends class Optimus Prime is an all-new, much more accurate mold compared to the 2007 Legends class Prime, having a much greater accuracy in both robot and vehicle mode. In particular, his vehicle mode isn't inexplicably missing one smokestack like the 2007 toy. It should be noted that he was molded in only one paintable plastic color, with red and blue deco patterns decked on it. The top of the truck's bunk (ending up on his back in robot mode) has a slot to combine with Jetfire. For some reason, this isn't mentioned in the instructions, though they're hardly needed.
Aware of the changes to the timestream and the potential for the entire Autobot race to be annihilated by Unicron, Optimus put into motion Operation Distant Thunder, a plan to undo the damage to the timeline caused by Ravage, restoring the events that were seen in the movie. This would mean that saving all the Autobots from Unicron would result in Prime and others such as Prowl, Wheeljack, Ironhide, and Ratchet would die per the original events. They hoped they would be able to at least partially avoid such an outcome by sending a message to their past selves about all they had learned.
Naturally, Optimus Prime got the biggest of the sets in the first year of Kre-O. The set can be built into a large long-nose tractor-trailer rig with a removable "sleeper" cab that hides a computer station, and a trailer that can carry the set's two motorcycles or open up to carry larger car builds. The robot mode build includes a huge Optimus, based largely on the live-action movie Optimus, though with a head based almost directly on the Classics Voyager Optimus. He is armed with a distressingly plain brick that fires pressure-launched missiles (aka his smokestacks). Most of the leftover parts in robot mode become a "headquarters" which is mostly just a random assemblage of mismatched-color panels and a pair of barricades. Both main builds leave numerous parts unused if you go expressly by the instructions, but hey, it's a building kit, surely you can find someplace to apply most of them.
If Optimus ordered his troops to come to the humans’ aid, they found themselves taking part in a struggle in futility, as the entire town was near-weightless, meaning they couldn’t put the humans anywhere where they wouldn’t float away once more. Then, the Autobots heard Decepticons approaching. Helpless in their current position, the Autobots were quickly eradicated by the Decepticons.